Journal: Bioconjugate chemistry

Article Title: A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo

doi: 10.1021/acs.bioconjchem.8b00177

Figure Lengend Snippet: (A) Thiomaltose trimethoprim (TM-TMP): A new trimethoprim prodrug with enhanced water solubility that targets bacteria. (B) Proposed cleavage of TM-TMP in the presence of exogenous thiols.

Article Snippet: Control groups included mice untreated with any drug, and mice treated with trimethoprim (Chem-Impex International Inc. Wood Dale, IL), while the experimental group was treated with thiomaltose-trimethoprim (TM-TMP).

Techniques: Solubility, Bacteria

Journal: Bioconjugate chemistry

Article Title: A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo

doi: 10.1021/acs.bioconjchem.8b00177

Figure Lengend Snippet: Synthesis of thiomaltose-trimethoprim (TM-TMP). (a) DCM, TEA, rt, 55%. (b) DCC, DMAP, TEA, DMF, rt, 29%. (c) CuI, DIPEA, DMSO, rt, 65%.

Article Snippet: Control groups included mice untreated with any drug, and mice treated with trimethoprim (Chem-Impex International Inc. Wood Dale, IL), while the experimental group was treated with thiomaltose-trimethoprim (TM-TMP).

Techniques:

Journal: iScience

Article Title: O -GlcNAcylation regulates OTX2’s proteostasis

doi: 10.1016/j.isci.2023.108184

Figure Lengend Snippet:

Article Snippet: Chloroquine diphosphate salt , Chem Impex , Cat# 22113.

Techniques: FLAG-tag, Virus, Recombinant, Binding Assay, Mutagenesis, Isolation, Reporter Gene Assay, Luciferase, Mass Spectrometry, Software